Cancer and VTE

Venous thromboembolism in women with gynecologic and breast cancer

. Olga Gavín Sebastián, Javier Trujillo-Santos, María Del Carmen Díaz-Pedroche, Pablo Demelo-Rodríguez, Sonia Otálora, Benjamin Brenner, José María Pedrajas, Alessandra Bura-Rivière, Luis Hernández-Blasco, Manuel Monreal; RIETE investigators. Venous thromboembolism in patients with breast, ovarian, and uterine cancer: a comparative analysis from the Registro Informatizado Enfermedad TromboEmbólica registry. Res Pract Thromb Haemost. 2025 Dec 17;10(1):103301. doi: 10.1016/j.rpth.2025.103301. eCollection 2026 Jan.

 

Thrombosis and breast cancer: should hormone therapy be continued after a VTE event?

. María Asunción Pérez-Jacoiste Asín, Ángeles Blanco Molina, Covadonga Gómez-Cuervo, María del Carmen Díaz-Pedroche, José María Pedrajas, Juan José López-Núñez, Aída Gil-Díaz, Alicia Alda-Lozano, Marijan Bosevski, Manuel Monreal; RIETE Investigators. Venous thromboembolism in women with hormone-dependent breast cancer. To continue or discontinue hormonal treatment? Insights from the RIETE registry. Thromb Res. 2024 Sep:241:109087. doi: 10.1016/j.thromres.2024.109087. Epub 2024 Jul 6.

 

Enoxaparin for long-term therapy

. Patricia Sigüenza, Juan J. López-Núñez, Conxita Falgá, Covadonga Gómez-Cuervo, Antoni Riera-Mestre, Aída Gil-Díaz, Peter Verhamme, Ana Cristina Montenegro, Cristina Barbagelata, Egidio Imbalzano, Manuel Monreal and RIETE Investigators. Enoxaparin for Long-Term Therapy of Venous Thromboembolism in Patients with Cancer and Renal Insufficiency. Thromb Haemost. 2024 Apr;124(4):363-373. doi: 10.1055/a-2191-7510. Epub 2023 Oct 13.

 

Cancer-associated distal DVT

. Jean-Philippe Galanaud, Javier Trujillo-Santos, Behnood Bikdeli, Laurent Bertoletti, Pierpaolo Di Micco, Géraldine Poénou, Conxita Falgá, Marija Zdraveska, Jorge Lima, Francisco Rivera-Cívico, Josefa Fernández Muixi, Manuel Monreal and RIETE Investigators. Clinical Presentation and Outcomes of Patients With Cancer-Associated Isolated Distal Deep Vein Thrombosis. J Clin Oncol. 2024 Feb 10;42(5):529-537. doi: 10.1200/JCO.23.00429. Epub 2023 Jul 20.

 

Identifying patients with prostate cancer and risk for haematuria

. Diana Paredes, María del Carmen Díaz-Pedroche, Covadonga Gómez-Cuervo, Asunción Pérez-Jacoiste, Reina Valle, Ángeles Blanco-Molina, Juan Bosco López-Sáez, Jose Meireles, Gabrielle Sarlon-Bartoli, Manuel Monreal and RIETE Investigators. Identifying patients with prostate cancer at increased risk for haematuria during anticoagulation for venous thromboembolism. Thromb Res. 2023 Dec:232:54-61. doi: 10.1016/j.thromres.2023.10.019. Epub 2023 Oct 30.

 

Patients with brain cancer and VTE

. Cecilia Becattini, Michela Giustozzi, José Portillo, Carmen Fernández-Capitán, José Luis Lobo, Ma Luisa Peris, Carme Font, Claire Grange, Ido Weinberg, Manuel Monreal and RIETE Investigators. Acute venous thromboembolism in patients with brain cancer: clinical course. Res Pract Thromb Haemost. 2023 Aug 20;7(6):102172. doi: 10.1016/j.rpth.2023.102172. eCollection 2023 Aug.

 

The RIETECAT study

. Javier Trujillo-Santos, Dominique Farge-Bancel, José María Pedrajas, Covadonga Gómez-Cuervo, Aitor Ballaz, Andrei Braester, Isabelle Mahé, Aurora Villalobos, José Antonio Porras, Manuel Monreal and RIETE Investigators. Enoxaparin versus dalteparin or tinzaparin in patients with cancer and venous thromboembolism: the RIETECAT study. Res Pract Thromb Haemost. 2022 Jun 3;6(4):e12736. doi: 10.1002/rth2.12736.

 

VTE associated with hematologic versus solid cancers

. Ramón Lecumberri, Pedro Ruiz-Artacho, Inna Tzoran, Benjamin Brenner, Dominique Farge-Bancel, Cihan Ay, Vladimir Rosa, Iria Francisco, Luis Manuel Hernández-Blasco, Javier Trujillo-Santos, Manuel Monreal and RIETE Investigators<Outcome of cancer-associated venous thromboembolism is more favorable among patients with hematologic malignancies than in those with solid tumors. Thromb Haemost. 2022 Sep;122(9):1594-1602. doi: 10.1055/a-1777-4006. Epub 2022 Feb 21.

 

How to treat cancer patients with incidental pulmonary embolism?

. Marisa Peris, Juan J López-Nuñez, Ana Maestre, David Jiménez, Alfonso Muriel, Behnood Bikdeli, Ido Weinberg, Cihan Ay, Lucia Mazzolai, Alicia Lorenzo, Manuel Monreal, RIETE InvestigatorsClinical characteristics and 3-month outcomes in cancer patients with incidental versus clinically suspected and confirmed pulmonary embolism. Eur Respir J. 2021 Jul 1;58(1):2002723. doi: 10.1183/13993003.02723-2020.

 

Vena cava filter in patients with cancer-associated venous thromboembolism?

. Andrés Quezada, David Jiménez, Behnood Bikdeli, Alfonso Muriel, Mario Aramberri, Luciano López-Jiménez, Joan Carles Sahuquillo, Remedios Otero, Angelo Porfidia, Manuel Monreal and RIETE Investigators. Outcomes after Vena Cava Filter Use in Patients with Cancer-Associated Venous Thromboembolism and Contraindications to Anticoagulation. Thromb Haemost. 2020 Jul;120(7):1035-1044. doi: 10.1055/s-0040-1710589.

 

Thrombocytopenia, venous thromboembolism and cancer: how to manage it

. Pedro Ruiz-Artacho, Javier Trujillo-Santos, Benjamin Brenner, Giovanni Barillari, Justo Ruiz-Ruiz, Manuel A Lorente, Peter Verhamme, Fernando Javier Vázquez, Ido Weinberg, Manuel Monreal and RIETE Investigators.Management and outcomes of cancer patients with venous thromboembolism presenting with thrombocytopenia. Thromb Res. 2020 Jul 10;195:139-145. doi: 10.1016/j.thromres.2020.07.021.

 

Venous thromboembolism as an independent predictor of death among patients with gastric cancer

. Kaushal Majmudar, Iva Golemi, Alfonso J Tafur, Jorge Del Toro, Adriana Visonà, Conxita Falgá, Joan Carles Sahuquillo, Manuel Alejandro Lorente, Antonella Tufano, Ido Weinberg, Pierpaolo Di Micco, Manuel Monreal and RIETE Investigators. Outcomes after venous thromboembolism in patients with gastric cancer: Analysis of the RIETE Registry. Vasc Med. 2020 Jun;25(3):210-217. doi: 10.1177/1358863X19893432. 

 

Prediction of mortality in patients with cancer-associated thrombosis

.Harry E Fuentes, Alfonso J Tafur, Joseph A Caprini, Adriano Alatri, Javier Trujillo-Santos, Dominique Farge-Bancel, Vladimir Rosa, Llorenç Font, Alicia Vilaseca, Manuel Monreal and RIETE Investigators. Prediction of early mortality in patients with cancer-associated thrombosis in the RIETE Database. Int Angiol. 2019 Jun;38(3):173-184.

 

A review of published studies on VTE therapy in patients with cancer in real world.

. López-Núñez JJ, Trujillo-Santos J, Monreal M. Management of venous thromboembolism in patients with cancer. J Thromb Haemost. 2018 Sep 23. doi: 10.1111/jth.14305

 

In cancer patients with VTE, myocardial infarction or ischemic stroke carry a similar mortality than PE recurrences

. Brenner B, Bikdeli B, Tzoran I, Madridano O, López-Reyes R, Suriñach JM, Blanco-Molina Á, Tufano A, Núñez JJL, Trujillo-Santos J, Monreal M; RIETE Investigators. Arterial Ischemic Events Are a Major Complication in Cancer Patients with Venous Thromboembolism. Am J Med. 2018 Sep;131(9):1095-1103. doi: 10.1016/j.amjmed.2018.04.037. Epub 2018 May 26.

 

Natural history of VTE in patients with pancreatic cancer

. Frere C, Trujillo-Santos J, Font C, Sampériz Á, Quintavalla R, González-Martínez J, Vázquez FJ, Lima J, Farge D, Monreal M; RIETE Investigators. Clinical Course of Venous Thromboembolism in Patients with Pancreatic Cancer: Insights from the RIETE Registry. Thromb Haemost. 2018 Jun;118(6):1119-1122. doi: 10.1055/s-0038-1642009. Epub 2018 Apr 21.

 

Validation of a prognostic score for hidden cancer

. Jara-Palomares L, Otero R, Jimenez D, Praena-Fernandez JM, Font C, Falga C, Soler S, Riesco D, Verhamme P, Monreal M; RIETE Registry. Validation of a prognostic score for hidden cancer in unprovoked venous thromboembolism. PLoS One. 2018 Mar 20;13(3):e0194673. doi: 10.1371/journal.pone.0194673. eCollection 2018.

 

Vitamin K antagonists in cancer patients with VTE

. Chai-Adisaksopha C, Iorio A, Crowther MA, de Miguel J, Salgado E, Zdraveska M, Fernández-Capitán C, Nieto JA, Barillari G, Bertoletti L, Monreal M; RIETE investigators. Vitamin K Antagonists After 6 Months of Low-Molecular-Weight Heparin in Cancer Patients with Venous Thromboembolism. Am J Med. 2018 Apr;131(4):430-437. doi: 10.1016/j.amjmed.2017.11.042. Epub 2017 Dec 20.

 

Ottawa VTE risk score in a cohort of patients with cancer

. Alatri A, Mazzolai L, Font C, Tafur A, Valle R, Marchena PJ, Ballaz A, Tiraferri E, Font L, Monreal M, Riete Investigators T. Low discriminating power of the modified Ottawa VTE risk score in a cohort of patients with cancer from the RIETE registry. Thromb Haemost. 2017 Jul 26;117(8):1630-1636. doi: 10.1160/TH17-02-0116. Epub 2017 May 18.

 

Venous thromboembolism in radiation therapy cancer patients

. Guy JB, Bertoletti L, Magné N, Rancoule C, Mahé I, Font C, Sanz O, Martín-Antorán JM, Pace F, Vela JR, Monreal M; RIETE investigators. Venous thromboembolism in radiation therapy cancer patients: Findings from the RIETE registry. Crit Rev Oncol Hematol. 2017 May;113:83-89. doi: 10.1016/j.critrevonc.2017.03.006. Epub 2017 Mar 9.

 

Predictors of active cancer thromboembolic outcomes

. Tafur AJ, Caprini JA, Cote L, Trujillo-Santos J, Del Toro J, Garcia-Bragado F, Tolosa C, Barillari G, Visona A, Monreal M; RIETE Investigators. Predictors of active cancer thromboembolic outcomes. RIETE experience of the Khorana score in cancer-associated thrombosis. Thromb Haemost. 2017 Jun 2;117(6):1192-1198. doi: 10.1160/TH16-11-0840. Epub 2017 Mar 9.

 

Venous thromboembolism and cancer: gender differences

. Martín-Martos F, Trujillo-Santos J, Del Toro J, Bura-Riviere A, Lorenzo A, Barillari G, Soler S, Mahè I, Sahuquillo JC, Monreal M; RIETE Investigators. Gender differences in patients with venous thromboembolism and five common sites of cancer. Thromb Res. 2017 Mar;151 Suppl 1:S16-S20. doi: 10.1016/S0049-3848(17)30061-0.

 

Clinical factors affecting the rates of VTE and cancer patients

. Trujillo-Santos J, Martos FM, Font C, Farge-Bancel D, Rosa V, Lorenzo A, Barrón M, Lorente MA, Pedrajas JM, Monreal M. Analysis of clinical factors affecting the rates of fatal pulmonary embolism and bleeding in cancer patients with venous thromboembolism. Heliyon. 2017 Jan 16;3(1):e00229. doi: 10.1016/j.heliyon. 2016.e00229. eCollection 2017 Jan.

 

Venous thromboembolism according to cancer site

. Mahé I, Chidiac J, Bertoletti L, Font C, Trujillo-Santos J, Peris M, Pérez Ductor C, Nieto S, Grandone E, Monreal M; RIETE investigators. The Clinical Course of Venous Thromboembolism May Differ According to Cancer Site. Am J Med. 2017 Mar;130(3):337-347. doi: 10.1016/j.amjmed.2016.10.017. Epub 2016 Nov 22

 

Prediction score for occult cancer in patients with VTE

. Jara-Palomares L, Otero R, Jimenez D, Carrier M, Tzoran I, Brenner B, Margeli M, Praena-Fernandez JM, Grandone E, Monreal M; RIETE Investigators. Development of a Risk Prediction Score for Occult Cancer in Patients With VTE. Chest. 2017 Mar;151(3):564-571. doi: 10.1016/j.chest.2016.10.025. Epub 2016 Nov 1.

 

Anticoagulant therapy in cancer patients with a pulmonary embolism

. Peris M, Jiménez D, Maestre A, Font C, Tafur AJ, Mazzolai L, Xifre B, Skride A, Dentali F, Monreal M; RIETE Investigators. Outcome during and after anticoagulant therapy in cancer patients with incidentally found pulmonary embolism. Eur Respir J. 2016 Nov;48(5):1360-1368. doi: 10.1183/13993003.00779-2016. Epub 2016 Sep 22.

 

Catheter-related thrombosis, thromboembolism and bleeding

. Valle R, Monreal Bosch M; RIETE Investigators. A RIETE registry analysis of recurrent thromboembolism and hemorrhage in patients with catheter-related thrombosis. J Vasc Surg Venous Lymphat Disord. 2015 Jul;3(3):243-50.e1. doi: 10.1016/j.jvsv.2015.03.002. Epub 2015 Jun 15.

 

VTE in patients with glioblastoma multiforme

. Portillo J, de la Rocha IV, Font L, Braester A, Madridano O, Peromingo JA, Apollonio A, Pagán B, Bascuñana J, Monreal M and the RIETE Investigations. Venous thromboembolism in patients with glioblastoma multiforme: Findings of the RIETE Registry. Thromb Res 2015 Dec; 136(6): 1199-203.

 

Disseminated intravascular coagulation in patients with cancer and VTE

. Spiezia L, Campello E, Trujillo-Santos J, Piovella C, Brenner B, Monreal M, Prandoni P and the RIETE Investigators. The impact of disseminated intravascular coagulation on the outcome of cancer patients with venous thromboembolism. Blood Coagul Fibrinolysis 2015 Sep; 26(6): 709-11.

 

Fatal PE and fatal bleeding

. Farge-Bancel D, Trujillo-Santos J, Debourdeau P, Bura-Riviere A, Rodriguez-Beltrán EM, Nieto JA, Peris ML, Zeltser D, Mazzolai L, Hij A, Monreal M and the RIETE Investigators. Fatal Events in Cancer Patients Receiving Anticoagulant Therapy for Venous Thromboembolism. Medicine (Baltimore) 2015 Aug; 94(32): e1235.

 

Gender differences in patients with cancer and VTE

. Martín-Martos F, Trujillo-Santos J, Barrón M, Vela J, Marchena PJ, Braester A, Hij A, Hernández-Blasco L, Verhamme P, Monreal M and RIETE investigators. Gender differences in cancer patients with acute venous thromboembolism. Thromb Res 2015 Feb; 135 Suppl 1: S12-5.

 

Immobilization or recent surgery in patients with cancer and VTE

. Trujillo-Santos J, Gussoni G, Gadelha T, Sánchez Muñoz-Torrero JF, Barrón M, López L, Ruiz-Ruiz J, Fernández-Capitán C, Lorente M, Monreal and the RIETE investigators. Influence of recent immobilization or surgery on mortality in cancer patients with venous thromboembolism. Thromb Res 2014 May; 133 Suppl 2: S29-34.

 

VTE in patients with cancer and renal insuficence

. Kooiman J, den Exter PL, Cannegieter SC, le Cessie S, Del Toro J, Sahuquillo JC, Pedrajas JM and Huisman MV. Impact of chronic kidney disease on the risk of clinical outcomes in patients with cancer-associated venous thromboembolism during anticoagulant treatment. J Thromb Haemost 2013 Nov; 11(11): 1968-76.

 

Predictors of death in cancer with VTE

. Gussoni G, Frasson S, La Regina M, Di Micco P, Monreal M; for the RIETE Investigators. Three-month mortality rate and clinical predictors in patients with venous thromboembolism and cancer. Findings from the RIETE Registry.Thromb Res 2013 Jan; 131(1): 24-30.

 

Predicting low risk patients of PE

. Exter PL, Gómez V, Jiménez D, Trujillo-Santos J, Muriel A, Huisman MV, Monreal M; for the RIETE investigators. A clinical prognostic model for the identification of low-risk patients with acute symptomatic pulmonary embolism and active cancer. Chest 2013 Jan; 143(1): 138-145.

 

Unsuspected pulmonary embolism in cancer patients

. Soler S, Delgado C, Ballaz A, Cisneros E, Malý R, Babalis D, Monreal M and the RIETE Investigators. Unsuspected pulmonary embolism in patients with cancer. Thromb Res 2012 Apr; 129 Suppl 1: S16-9.

 

Long-term treatment with LMWH for VTE in cancer patients

. Marchena PJ, Nieto JA, Guil M, García-Bragado F, Rabuñal R, Boccalon H, Trujillo-Santos J, Monreal M and the RIETE Investigators. Long-term therapy with low-molecular-weight heparin in cancer patients with venous thromboembolism. Thromb Haemost 2012 Jan; 107(1): 37-43.

 

Prevention of VTE

. Trujillo-Santos J, Fernández-Capitán C, Rosa V, Gutiérrez MR, Oribe M, Mahe I, Monreal M and the RIETE Investigators. Prevention of venous thromboembolism in patients with cancer in Spain. J Coagul Disord 2011 Oct; 3(1): 64-68.

 

30-day mortality in women with cancer and VTE

. Trujillo-Santos J, Casas JM, Casado I, Samperiz AL, Quintavalla R, Sahuquillo JC, Monreal M, and the RIETE Investigators. Thirty-day mortality rate in women with cancer and venous thromboembolism. Findings from the RIETE Registry. Thromb Res 2011 Feb;127 Suppl 3:S1-4.

 

Bleeding during treatment of VTE

. Trujillo-Santos J, Nieto J A, Ruiz-Gamietea A, López-Jiménez L, García-Bragado F, Quintavalla R, Monreal M for the RIETE Investigators. Bleeding Complications associated with anticoagulant therapy in patients with cancer. Thromb Res 2010 Apr; 125 Suppl 2:S58-61.

 

Prediction of recurrences or bleeding in women with cancer

. Trujillo-Santos J, Ruiz-Gamietea A, Luque JM, Samperiz AL, García-Bragado F, Todolí JA, Monreal M, for the RIETE Investigators. Predicting recurrences or major bleeding in women with cancer and venous thromboembolism. Findings from the RIETE Registry. Thromb Res 2009; 123 Suppl 2: S10-5.

 

Leukocytosis and outcomes

. Trujillo-Santos J, Di Micco P, Iannuzzo M, Lecumberri R, Guijarro R, Madridano O, Monreal M for the RIETE Investigators. Elevated white blood cell count and outcome in cancer patients with venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 2008 Nov; 100(5): 905-11.

 

Recurrences and bleeding in patients with solid cancer and VTE

. Prandoni P, Trujillo-Santos J, Surico T, Dalla Valle F, Piccioli A, Monreal M for the RIETE Investigators. Recurrent thromboembolism and major bleeding during oral anticoagulant therapy in patients with solid cancer: findings from the RIETE Registry. Haematologica 2008 Sep; 93(9):1432-4.

 

Prediction of outcomes in cancer patients

. Trujillo-Santos J, Nieto JA, Tiberio G, Piccioli A, Di Micco P, Prandoni P, Monreal M for the RIETE Investigators. Predicting recurrences or major bleeding in cancer patients with venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 2008 Sep; 100(3): 435-9.

 

Hidden cancer in patients with VTE

. Trujillo-Santos J, Prandoni P, Rivron-Guillot K, Román P, Sánchez R, Tiberio G, Monreal M and the RIETE Investigators. Clinical outcome in patients with venous thromboembolism and hidden cancer: findings from the RIETE Registry. J Thromb Haemost 2008 Feb; 6(2): 251-55.

 

RIETE lessons in patients with cancer and VTE

. Monreal M, Prandoni P, Di Micco P, Barba R, Trujillo-Santos J, Rivron-Guillot K, Decousus H. Lessons learned from Cancer/VTE Registries: Report from RIETE. Thromb Res 2007; 120 (2): S62-S63.

 

Upper extremity thrombosis in cancer

. Monreal M, Muñoz FJ, Rosa V, Romero C, Román P, Di Micco P, Prandoni P. Upper extremity DVT in oncological patients: analysis of risk factors. Data from the RIETE Registry. Exp Oncol 2006 Sep; 28(3): 245-7.

 

Fatal PE and fatal bleeding in cancer

. Monreal M, Falgá C, Valdés M, Suárez C, Gabriel F, Tolosa C, Montes J for the RIETE Investigators. Fatal pulmonary embolism and fatal bleeding in cancer patients with venous thromboembolism: findings from the RIETE Registry. J Thromb Haemost 2006 Sep; 4(9):1950-6.

 

VTE and outcome in cancer patients

. Monreal M, Falgá C, Vilaseca B, Suárez C, Gabriel F, Tolosa C, Montes J for the RIETE investigators.Clinical outcomes in cancer patients with concurrent venous thromboembolism: findings from the RIETE Registry. Haematologica Reports 2005 Oct; 1(9): 64-65.