VTE treatment

 

 

What happens in patients with acute PE in whom we cannot administer anticoagulants?

Nieto JA, Vicente JA, Prieto LM, Jiménez D, Bikdeli B, Rivas A, Porras JA, Morales MDV, Bosevski M, Monreal M; RIETE Investigators. Thirty-day outcomes in patients with acute pulmonary embolism who discontinued anticoagulant therapy before 90 days. Am Heart J. 2018 Sep 5;206:1-10. doi: 10.1016/j.ahj.2018.08.014.

 

Outcomes in VTE patients presenting with major bleeding while receiving VKAs for VTE

Moustafa F, Stehouwer A, Kamphuisen P, Sahuquillo JC, Sampériz Á, Alfonso M, Pace F, Suriñach JM, Blanco-Molina Á, Mismetti P, Monreal M; RIETE Investigators. Management and outcome of major bleeding in patients receiving vitamin K antagonists for venous thromboembolism. Thromb Res. 2018 Sep 22;171:74-80. doi: 10.1016/j.thromres.2018.09.049.

 

Outcomes during anticoagulation in patients with symptomatic vs. incidental splanchnic vein thrombosis

. Tufano A, Ageno W, Di Micco P, Niglio A, Rosa V, Ballaz A, Braester A, Rubio CM, Isern V, Imbalzano E, Monreal M; RIETE Investigators. Outcomes during anticoagulation in patients with symptomatic vs. incidental splanchnic vein thrombosis. Thromb Res. 2018 Apr;164:69-74. doi: 10.1016/j.thromres.2018.02.143. Epub 2018 Mar 2.

 

Anticoagulant therapy in patients with inflammatory bowel disease

. Lobo JL, Garcia-Fuertes JA, Trujillo-Santos J, Merah A, Blanco-Molina MÁ, Casado I, Hirmerova J, De Miguel J, Salgado E, Monreal M; RIETE Investigators. Anticoagulant therapy for venous thromboembolism in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2018 May;30(5):526-530. doi: 10.1097/MEG.0000000000001084.

 

Anemia and bleeding in patients receiving anticoagulant therapy

. Kuperman A, López-Reyes R, Bosco LJ, Lorenzo A, José B, Farge Bancel D, Alfonso M, Lumbierres M, Stemer G, Monreal Bosch M, Braester A; RIETE Investigators. Anemia and bleeding in patients receiving anticoagulant therapy for venous thromboembolism. J Thromb Thrombolysis. 2018 Apr;45(3):360-368. doi: 10.1007/s11239-018-1610-9.

 

Real-life use of anticoagulants in patients excluded in clinical trials on direct oral anticoagulants

. Moustafa F, Pesavento R, di Micco P, González-Martínez J, Quintavalla R, Peris ML, Porras JA, Falvo N, Baños P, Monreal M; RIETE Investigators. Real-life Use of Anticoagulants in Venous Thromboembolism With a Focus on Patients With Exclusion Criteria for Direct Oral Anticoagulants. Clin Pharmacol Ther. 2018 Apr;103(4):684-691. doi: 10.1002/cpt.781. Epub 2017 Aug 7.

 

Anticoagulant therapy during hormonal use

. Blanco-Molina Á, Trujillo-Santos J, Pesavento R, Rosa V, Falgá C, Tolosa C, Mazzolai L, Sampériz Á, Duce R, Monreal M; RIETE Investigators. Outcome after discontinuing anticoagulant therapy in women with venous thromboembolism during hormonal use. Thromb Res. 2017 Mar;151 Suppl 1:S6-S10. doi: 10.1016/S0049-3848(17)30059-2.

 

Uterine bleeding during a VTE therapy

. Moustafa F, Fernández S, Fernández-Capitán C, Nieto JA, Pedrajas JM, Visoná A, Valero B, Marchena PJ, Braester A, Monreal M; RIETE Investigators. Uterine bleeding during anticoagulation in women with venous thromboembolism. Thromb Res. 2017 Mar;151 Suppl 1:S1-S5. doi: 10.1016/S0049-3848(17)30058-0.

 

Once versus twice daily enoxaparin in initial treatment of VTE

. Trujillo-Santos J, Bergmann JF, Bortoluzzi C, López-Reyes R, Giorgi-Pierfranceschi M, López-Sáez JB, Ferrazzi P, Bascuñana J, Suriñach JM, Monreal M. Once versus twice daily enoxaparin for the initial treatment of acute venous thromboembolism. J Thromb Haemost. 2017 Mar;15(3):429-438. doi: 10.1111/jth.13616. Epub 2017 Feb 18.

 

Outcomes associated with inferior vena cava filters

. Mellado M, Pijoan JI, Jiménez D, Muriel A, Aujesky D, Bertoletti L, Decousus H, Barrios D, Clará A, Yusen RD, Monreal M; RIETE Investigators. Outcomes Associated With Inferior Vena Cava Filters Among Patients With Thromboembolic Recurrence During Anticoagulant Therapy. JACC Cardiovasc Interv. 2016 Dec 12;9(23):2440-2448. doi: 10.1016/j.jcin.2016.08.039. Epub 2016 Nov 9.

 

Anticoagulant therapy in cancer patients with a pulmonary embolism

. Peris M, Jiménez D, Maestre A, Font C, Tafur AJ, Mazzolai L, Xifre B, Skride A, Dentali F, Monreal M; RIETE Investigators. Outcome during and after anticoagulant therapy in cancer patients with incidentally found pulmonary embolism. Eur Respir J. 2016 Nov;48(5):1360-1368. doi: 10.1183/13993003.00779-2016. Epub 2016 Sep 22.

 

Real-life treatment of venous thromboembolism with direct oral anticoagulants

. Trujillo-Santos J, Di Micco P, Dentali F, Douketis J, Díaz-Peromingo JA, Núñez MJ, Cañas I, Mastroiacovo D, Saraiva de Sousa M, Monreal M; RIETE Investigators. Real-life treatment of venous thromboembolism with direct oral anticoagulants: The influence of recommended dosing and regimens. Thromb Haemost. 2017 Jan 26;117(2):382-389. doi: 10.1160/TH16-07-0494. Epub 2016 Oct 27.

 

Arterial ischemia after VTE

. Madridano O, Del Toro J, Lorenzo A, Martín M, Gómez Cerezo J, Hernández L, Prandoni P, Monreal M; RIETE Investigators. Subsequent arterial ischemic events in patients receiving anticoagulant therapy for venous thromboembolism. J Vasc Surg Venous Lymphat Disord. 2015 Apr;3(2):135-141.e1. doi: 10.1016/j.jvsv.2014.11.002. Epub 2015 Mar 13.

 

VTE in patients with negative D-dimer levels

. Soto MJ, Grau E, Gadelha T, Palareti G, Bounameaux H, Villalta J, Monreal M and the RIETE investigators. Clinical significance of negative D-dimer level in patients with confirmed venous thromboembolism. Findings from the RIETE Registry. J Thromb Haemost 2011 Feb; 9(2): 407-10.

 

Major bleeding and death

. Prandoni P, Trujillo-Santos J, Sánchez-Cantalejo E, Dalla Valle F, Piovella C, Pesavento R, Nieto Rodríguez JA, Monreal M for the RIETE Group. Major bleeding as a predictor of mortality in patients with venous thromboembolism: findings from the RIETE Registry. J Thromb Haemost 2010 Nov; 8(11): 2575-7.

 

VTE recurrences during therapy

. Lobo JL, Jiménez D, Orue MT, Grau E, Naufall D, Madridano O, Monreal M and the RIETE Investigators. Recurrent venous thromboembolism during coumarin therapy. Data from the computerised Registry of patients with venous thromboembolism. Brit J Haematol 2007 Aug; 138 (3): 400-3.

 

Platelet count and bleeding during VKA

. Giorgi-Pierfranceschi M, Di Micco P, Cattabiani C, Guida A, Pagán B, Morales MV, Salgado E, Suriñach JM, Tolosa C, Monreal M and the RIETE Investigators. Platelet count and major bleeding in patients receiving vitamin K antagonists for acute venous thromboembolism, Findings from real world clinical practice. Medicine (Baltimore) 2015 Nov; 94(47): e1915.

 

How do we treat VTE in Italy?

. Dentali F, Di Micco G, Giorgi Pierfranceschi M, Gussoni G, Barillari G, Amitrano M, Fontanella A, Lodigiani C, Guida A, Visonà A, Monreal and Di Micco P. Rate and duration of hospitalization for deep vein thrombosis and pulmonary embolism in real-world clinical practice. Ann Med 2015 Sep 30: 1-9.

 

Arterial complications after a VTE

. Madridano O, del Toro J, Lorenzo A, Martin M, Gómez Cerezo J, Prandoni P, Hernández L, Prandoni P, Monreal M, and the RIETE Investigators. Subsequent arterial ischemic events in patients receiving anticoagulant therapy for venous thromboembolism. J Vasc Surg: Venous and Lymphatic Disorders 2015 Apr; 3 (2):135-141.

 

VTE is often generated at home

. López-Reyes R, Nauffal D, Ballester M, Martín-Antorán JM, de Sousa MS, Riera-Mestre A, Ruiz-Ruiz J, Fernández-Capitán C, Uresandi F, Monreal M and the RIETE Investigators. Venous thromboembolism in patients immobilised at home. Eur Respir J 2015 Jun; 45(6): 1728-31.

 

How do we treat VTE?

. Mahé I, Sterpu R, Bertoletti L, López-Jiménez L, Mellado Joan M, Trujillo-Santos J, Ballaz A, Hernández Blasco LM, Marchena PJ, Monreal M and the RIETE investigators. Long-Term anticoagulant therapy of patients with venous thromboembolism. What are the practices? PLoS One 2015 Jun 15; 10(6):e0128741.

 

How long do we treat VTE?

. Ageno W, Sampériz A, Caballero R, Dentali F, Di Micco P, Prandoni P, Becattini C, Uresandi F, Verhamme P, Monreal M and the RIETE investigators. Duration of anticoagulation after venous thromboembolism in real world clinical practice. Thromb Res 2015 Apr; 135(4): 666-72.

 

Fondaparinux in the treatment for VTE

. Pesavento R, Amitrano M, Trujillo-Santos J, Di Micco P, López-Jiménez L, Falgá C, García-Bragado F, Piovella C, Prandoni P, Monreal M and the RIETE Investigators. Fondaparinux in the initial and long-term treatment of venous thromboembolism. Thromb Res 2015 Feb; 135(2): 311-7.

 

Comparison of 4 scales to identify the risk of bleeding

. Piovella C, Dalla Valle F, Trujillo-Santos J, Pesavento R, López L, Font L, Valle R, Nauffal D, Monreal M, Prandoni P and the RIETE Investigators.Comparison of four scores to predict major bleeding in patients receiving anticoagulation for venous thromboembolism. Findings from the RIETE Registry. Intern Emerg Med 2014 Dec; 9(8): 847-52.

 

Antiplatelet drugs and anticoagulation

. Tzoran I, Brenner B, Sakharov G, Trujillo-Santos J, Lorenzo A, Madridano O, López-Sáez JB, Monreal M and RIETE investigators. Clinical outcome in patients with venous thromboembolism receiving concomitant anticoagulant and antiplatelet therapy. Eur J Intern Med 2014 Nov; 25(9): 821-5.

 

Sex differences

. Blanco-Molina A, Enea I, Gadelha T, Tufano A, Bura-Riviere A, Di Micco P, Bounameaux H, González J, Villalta J, Monreal M. Sex differences in patients receiving anticoagulant therapy for venous thromboembolism. Medicine (Baltimore). 2014 Oct; 93(17): 309-17.

 

Platelet count nd outcome

. Di Micco P, Ruiz-Giménez N, Nieto JA, Aujesky D, Del Molino F, Valle R, Barrón M, Maestre A, Monreal M, and the RIETE investigators. Platelet count and outcome in patients with acute venous thromboembolism. Thromb Haemost 2013 Oct; 110(5): 1025-34.

 

Case-fatality rates of recurrences of bleeding

. Lecumberri R, Alfonso A, Jiménez D, Fernández Capitán C, Prandoni P, Wells PS, Vidal G, Barillari G, Monreal M, and the RIETE Investigators. Dynamics of case-fatality rates of recurrent thromboembolism and major bleeding in patients treated for venous thromboembolism. Thromb Haemost 2013 Sept; 110(4): 834-43.

 

Validation of the prognostic score for fatal bleeding

. Nieto JA, Solano R, Trapero Iglesias N, Ruiz-Giménez N, Fernández-Capitán C, Valero B, Tiberio G, Bura-Riviere A, Monreal M for the RIETE Investigators. Validation of a score for predicting fatal bleeding in patients receiving anticoagulation for venous thromboembolism. Thromb Res 2013 Aug; 132(2): 175-9.

 

VTE in patients with chronic lung disease

. Bertoletti L, Quenet S, Mismetti P, Hernández L, Martín-Villasclaras JJ, Tolosa C, Valdés M, Barrón M, Todolí J, Monreal M and the RIETE Investigators. Clinical presentation and outcome of venous thromboembolism in COPD. Eur Respir J 2012 Apr; 39(4): 862-8.

 

Fever in patients with VTE

. Barba R, Di Micco P, Blanco-Molina A, Delgado C, Cisneros E, Villalta J, Morales MV, Bura-Riviere A, Debourdeau P, Monreal M, for the RIETE Investigators. Fever and deep venous thrombosis. Findings from the RIETE Registry. Thromb Thrombolysis. 2011 Oct; 32(3): 288-92.

 

Thrombocytopenia due to heparin

. Falvo N, Bonithon-Kopp C, Rivron-Guillot K, Todolí JA, Jiménez-Gil M, Di Micco P, Monreal M, for the RIETE Investigators. Heparin-associated thrombocytopenia in 24,401 patients with venous thromboembolism: findings from the RIETE Registry. J Thromb Haemost 2011 Sep; 9(9):1761-8.

 

Mortality on weekends vs. working days

. Lecumberri R, Soler S, del Toro J, Barba R, Rosa V, Ciammaichella M, Monreal M. Effect of the time of diagnosis on outcome in patients with acute venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 2011 Jan; 105(1): 45-51.

 

In patients vs. out patients

. Maestre A, Sánchez R, Rosa V, Aujesky D, Lorenzo A, Barillari G, Monreal M and the RIETE Investigators. Clinical characteristics and outcome of inpatients versus outpatients with venous thromboembolism. Findings from the RIETE Registry. Eur J Intern Med 2010 Oct; 21(5): 377-82

 

Prognostic score for fatal bleeding

. Nieto JA, Solano R, Ruiz-Ribó MD, Ruiz-Giménez N, Prandoni P, Kearon C, Monreal M and the RIETE Investigators. Fatal bleeding in patients receiving anticoagulant therapy for venous thromboembolism: findings from the RIETE Registry. J Thromb Haemost 2010 Jun; 8(6):1216-22.

 

Recent major bleeding

. Nieto JA, Camara T, González-Higueras E, Ruiz-Giménez N, Guijarro R, Marchena PJ, Monreal M for the RIETE Investigators. Clinical outcome of patients with major bleeding after venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 2008 Nov; 100(5): 789-96.

 

Prognostic score for major bleeding

. Ruiz-Giménez N, Suárez C, González R, Nieto JA, Todolí JA, Sampériz AL, Monreal M and the RIETE Investigators. Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 2008 Jul; 100(1): 26-31.

 

Obesity and mortality

. Barba R, Zapatero A, Losa JE, Valdés V, Todolí JA, Di Micco P, Monreal M and the RIETE Investigators. Body mass index and mortality in patients with acute venous thromboembolism: findings from the RIETE Registry. J Thromb Haemost 2008 Apr; 6(4): 595-600.

 

VTE in patients with extreme body weight

. Barba R, Marco J, Martín-Álvarez H, Rondón P, Fernández-Capitán C, García-Bragado F, Monreal M for the RIETE Investigators. The influence of extreme body weight on clinical outcome of patients with venous thromboembolism: findings from a prospective Registry (RIETE). J Thromb Haemost 2005 May; 3(5): 856-62.

 

Bed rest in initial therapy

. Trujillo-Santos J, Perea-Milla E, Jiménez-Puente A, Sánchez-Cantalejo E, Del Toro J, Grau E, Monreal M and the RIETE Investigators. Bed rest or ambulation in the initial treatment of patients with acute deep vein thrombosis or pulmonary embolism: findings from the RIETE Registry. Chest 2005 May; 127(5): 1631-6.

 

 

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The RIETE Registry is the world’s largest database on patients with venous thromboembolism (VTE).

RIETE Registry is a Fundación Fuente project

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Last update

September 2018

 

 

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